高等学校化学学报2012，Vol.33Issue(10)：2138-2140,3.DOI:10.7503/cjcu20120624
侧链含炔丙基的PLGA-PEG-PLGA三嵌段共聚物的合成与表征
Synthesis and Characterization of PLGA-PEG-PLGA Triblock Copolymer with Side Propargyl Groups
摘要
Abstract
In order to introduce the propargyl groups to the side chains of biodegradable polyester which available for the attachment of functionality using "click" chemistry, the propargyl glycolide(PG) monomer was synthesized and characterized by FTIR and 13C NMR. Then, a series of PLGA-PEG-PLGA tri-block copoly-mers with side propargyl groups was prepared by bulk ring-opening copolymerization of L-lactide and propargyl glycolide using 1,4-dimethylaminopyridine( DMAP) as a catalyst and polyethylene glycol(PEG) as a cointia-tor with different feed ratios(nPEC : nPG: nL-LA). The structure and properties of the PLGA-PEG-PLGA tri-block copolymers with side propargyl groups were studied by FTIR, 1H NMR and gel permeation chromatography.关键词
生物降解聚酯/改性/点击化学/炔丙基化乙交酯/PLGA-PEG-PLGA三嵌段共聚物Key words
Biodegradable polyester/ Modification/ Click chemistry/ Propargyl glycolide/ PLGA-PEG-PLGA triblock copolymer分类
化学化工引用本文复制引用
徐宠恩,杨静,罗丙红,李建华,徐湾,周长忍..侧链含炔丙基的PLGA-PEG-PLGA三嵌段共聚物的合成与表征[J].高等学校化学学报,2012,33(10):2138-2140,3.基金项目
国家自然科学基金(批准号:81171459)、广东省自然科学基金(批准号:10151063201000033)和暨南大学"211工程"生物材料与组织工程创新基金(批准号:50621030)资助. （批准号:81171459）
