高等学校化学学报2012，Vol.33Issue(10)：2223-2228,6.DOI:10.7503/cjcu20120263
3-脱氢莽草酸甲酯与肼类化合物反应的选择性
Selective Derivation of (-)-Methyl-3-dehydroshikimate with Hydrazine Compounds
摘要
Abstract
The purpose of this paper is to achieve the high value-added and diversified transformation of the renewable biomass (-) -shikimic acid, starting from which, the key intermediate ( -)-methyl-3-dehydro-shikimiate was readily obtained through esterification and 2-iodoxybenzoic acid-oxidation. The reaction of (-)-methyl-3-dehydroshikimiate with hydrazine, acethydrazide, hydrazinobenzene and acetamide could give rise to non-aromatization products (2a and 2d) , partial-aromatization products (2b) and aromatization products (2c and 2e) selectively under different conditions. The present methodology with good diversity, high selectivity and operational simplicity provides a new paradigm for the transformation of bio-based and non-food feedstock.关键词
3-脱氢莽草酸甲酯/肼类化合物/反应选择性/可再生资源Key words
(-)-Methyl-3-dehydroshikimate/ Hydrazine compound/ Selectivity/ Renewable source分类
化学化工引用本文复制引用
吴伟,张恩生,魏文,黄桐堃,刘新伟,杨少凡,邹永..3-脱氢莽草酸甲酯与肼类化合物反应的选择性[J].高等学校化学学报,2012,33(10):2223-2228,6.基金项目
国家自然科学基金(批准号:21272280)、广东省中国科学院全面战略合作项目(批准号:2009B091300125)、广东省战略新兴产业核心技术攻关项目(批准号:2011A081401002)、"十二五"国家重大新药创制项目(批准号:2011ZX09202-101-07)和广州市科技计划项目(批准号:12A51061555)资助. （批准号:21272280）
