广东医学2012，Vol.33Issue(20)：3040-3042,3.
槲皮素对野百合碱诱导的大鼠肺动脉高压动脉内膜增殖的影响
Effects of quercetin on proliferation of arterial endothelium of rats with monocrotaline-induced pulmonary arterial hypertension
李波 1刘映峰 2陈灿 3黄石安 3高汉华 3庞玲品3
作者信息
- 1. 南方医科大学研究生学院,广州510515
- 2. 南方医科大学珠江医院心血管内科,广州510282
- 3. 广东医学院附属医院心血管内科二区,广东湛江524001
- 折叠
摘要
Abstract
Objective To investigate the effects of quercetin on the proliferation of arterial endothelium of rats with monocrotaline (MCT) induced pulmonary hypertension. Methods Thirty male SD rats were randomly divided into three groups (n = 10) : control group, MCT group and prevention group. The expression of factor VK:Ag in pulmonary arterial was assessed by immunohistochemistry and Western hlot for evaluation of the endodermis proliferation of the pulmonary artery. Meanwhile, the morphologic change in pulmunary artery was observed. Results The expression of factor VI: Ag was significantly increased in MCT group than that in control group and prevention group (P < 0. 05). In prevention group, the expression of factor VHI -. Ag was also significantly higher than that in control group ( P < 0. 05 ) . Conclusion Quercetin can reduce the MCT - induced endodermis proliferation.
关键词
肺动脉高压/槲皮素/内膜增殖Key words
pulmonary hypertension/ quercetin/ endodermis proliferation引用本文复制引用
李波,刘映峰,陈灿,黄石安,高汉华,庞玲品..槲皮素对野百合碱诱导的大鼠肺动脉高压动脉内膜增殖的影响[J].广东医学,2012,33(20):3040-3042,3.
