广东医学2012，Vol.33Issue(21)：3201-3204,4.
荔枝核总黄酮抗大鼠肝纤维化的作用及其对核转录因子-κB p65表达的影响
Effects of total flavone from Litchi chinensis Sonn on the expression of NF-κB p65 and hepatic fibrosis in rats
摘要
Abstract
Objective To investigate the effects of total flavone from Litchi chinensis Sonn (TFL) on the expression of NF - κB and hepatic fibrosis in rats. Methods The rat model of hepatic fibrosis was established by intraperitoneal injection of dimethylnitrosamine. TFL, colchicine and saline lavage were given to the subjects in the TFL, model and col-chicine groups, respectively. Serum ALT and AST were measured at 6th week, and the pathological observation was also performed on left liver lobes with HE straining while S - P immunohistochemical staining using polyclonal antibodies a-gainst NF - κB was applied in assessment of NF - κB. Results The serum ALT and AST in TFL and colchicine groups were significantly lower than that in model group ( P < 0. 05 ) . Meanwhile, significant improvement of hepatic fibrosis and suppression of in NF - κB were revealed in TFL group than that in model group ( P < 0. 05 ) . Conclusion TEL alleviates the hepatic fibrosis in rats, which may involve the inhibition of NF - κB.关键词
荔枝核总黄酮/肝纤维化/核转录因子-κBKey words
flavone from Litchi chinensis Sonn/ hepatic fibrosis/ nuclear factor - KB引用本文复制引用
罗伟生,欧士钰,靳雅玲,覃浩,孙旭锐..荔枝核总黄酮抗大鼠肝纤维化的作用及其对核转录因子-κB p65表达的影响[J].广东医学,2012,33(21):3201-3204,4.基金项目
广西壮族自治区卫生厅医疗卫生重点科研课题(编号:重2010052) （编号:重2010052）
