广东医学2012，Vol.33Issue(21)：3233-3236,4.
血浆脑钠肽正常水平对重度慢性心力衰竭患者预后的影响
Effects of B-type natriuretic peptide on prognosis in patients with severe chronic heart failure
胡斌 1周敬群1
作者信息
- 1. 三峡大学仁和医院心血管内科,湖北宜昌,443001
- 折叠
摘要
Abstract
Objective To determine the prognostic effects of B -type natriureic peptide (BNP) on patients with severe chronic heart failure ( CHF) . Methods Retrospective analysis was carried out on the clinical data of the in - hospital patients with CHF ( New York Heart Association class Ⅲ or Ⅳ ) . All patients were followed up by telephone contact. Patients were divided into normal - BNP ( ≤100 pg/mL) and abnormal - BNP ( > 100 pg/mL) groups according to the plasma BNP in the first time admitted to hospital; and divided into survive and death groups according to the result of follow - up. Univariate and multivariate Cox proportional hazard models were applied to determinate the difference of prognosis between normal - BNP group and abnormal - BNP group. The correlation between plasma BNP and prognosis of severe CHF patients was evaluated through independent t -teat, % -test and multivariate logistic regression analysis. Results A total of 592 in - hospital patients were enrolled from January 2007 to January 2010, with 106 ( 17. 91% ) and 486 (82. 09% ) patients in normal - BNP and abnormal - BNP groups, respectively. Over the 2 years follow - up, 176 (29. 73% ) deaths were reported. The all - cause mortalities were 68. 85% and 24. 91% in normal - BNP and abnormal - BNP groups, respectively. According to multivariable logistic analysis, normal plasma BNP, course of heart failure, NYHA classification, LVEF, LVEDd and the use of (3 - Blocker significant independent predicted factors of the death of patients with severe CHF. Conclusion To the patients with severe CHF, the normal - BNP patients suffer worse prognosis. The normal plasma BNP is an independent risk factor of death in patients with severe CHF.
关键词
慢性心力衰竭/脑钠肽/预后Key words
chronic heart failure/ natriuretic peptide/ prognosis引用本文复制引用
胡斌,周敬群..血浆脑钠肽正常水平对重度慢性心力衰竭患者预后的影响[J].广东医学,2012,33(21):3233-3236,4.
