广东医学2012，Vol.33Issue(22)：3409-3412,4.
巨噬细胞移动抑制因子在大肠癌中的表达及意义
The expression and significance of macrophage migration inhibitory factor in colorectal cancer.
摘要
Abstract
Objective To detect the macrophage migration inhibitory factor ( MIF) in normal colon tissue , colorectal hyperplastic polyps , colorectal adenoma and colorectal cancer , thus to evaluate the early diagnostic efficacy for color -ectal cancer. Methods The MIF was detected in 50 cases of colorectal cancer , 30 cases of colorectal adenomas , 10 cases of colorectal hyperplastic polyps and 10 cases of normal colon tissue. Results The positive rates of MIF were 0, 10. 0% , 73. 3% and 58. 0% in normal colon , colorectal hyperplastic polyps , colorectal adenoma and colorectal cancer , respectively, with significant difference between colorectal cancer and normal colon tissue or colorectal hyperplastic polyps (P < 0. 05 ). The MIF expression was significantly correlated with the histological grade and age (P < 0. 05 ). However, there was no significant correlation between the MIF expression and sex , ethnicity, tumor size, clinical stage , lymph node metastasis, serum CEA, serum CA199 or distant metastasis (P>0. 05). Conclusion MIF is highly expressed in colorectal adenoma and colorectal cancer , suggesting it may be involved in the process of early lesions of colorectal cancer . MIF expression is closely correlated with the histological grade , suggesting that MIF may be correlated to the degree of malig -nancy of colorectal cancer.关键词
巨噬细胞移动抑制因子/大肠癌/免疫组织化学Key words
macrophage migration inhibitory factor / colorectal cancer / immunohistochemistry引用本文复制引用
余月华,马彬,翟惠虹,冯珊珊..巨噬细胞移动抑制因子在大肠癌中的表达及意义[J].广东医学,2012,33(22):3409-3412,4.基金项目
宁夏自然科学基金资助项目(编号:NZ11223) （编号:NZ11223）
