广东药学院学报2012，Vol.28Issue(5)：475-478,4.DOI:10.3969/j.issn.1006-8783.2012.05.003
粉末直接压片法制备硝苯地平片及其稳定性考察
Preparation and stability of nifedipine tablets by direct powder compression
刘春平 1刘再强 2全向阳 1向飞军1
作者信息
- 1. 广东康美药物研究院有限公司,广东广州510006
- 2. 康美药业股份有限公司,广东普宁515300
- 折叠
摘要
Abstract
Objective To optimize the preparation process of nifedipine tablets by direct powder compression. Methods The formulation of nifedipine tablets was optimized by orthogonal experiment design with angle of repose, friability and dissolution as evaluation indexes. The samples were prepared and their quality was inspected. Results The selected formulation had promising powder fluidity and drug dissolution rate which reached more than 95% in 60 min. The quality of the tablets was accorded with the relative requirements. After 6 months of accelerated test and storage at room temperature, the appearance, content, related substance and dissolution of the samples had no significant change. Conclusion The selected formulation and process were characteristic of convenient operation, economy, short production cycle, stable product quality, and was suitable for industrialized production.关键词
硝苯地平/粉末直接压片/稳定性/制备工艺/溶出度Key words
nifedipine/ direct powder compression tablets/ stability/ preparation process/ dissolution分类
医药卫生引用本文复制引用
刘春平,刘再强,全向阳,向飞军..粉末直接压片法制备硝苯地平片及其稳定性考察[J].广东药学院学报,2012,28(5):475-478,4.
