广东药学院学报2012，Vol.28Issue(5)：537-539,3.DOI:10.3969/j.issn.1006-8783.2012.05.018
苹果多酚对Triton WR-1339诱发的高脂血症小鼠抗氧化能力的影响
Effect of apple polyphenols on antioxidant ability in Triton WR-1339-induced hyperlipidemic mice
胡明月 1姚楠 2曾晓会 2黄雪君 2何蓉蓉 3栗原博3
作者信息
- 1. 广东岭南职业技术学院,广东广州510063
- 2. 广东省中医研究所,广东广州510095
- 3. 暨南大学中药及天然药物研究所,广东广州510632
- 折叠
摘要
Abstract
Objective To investigate the antioxidant effect of apple polyphenols extract (APE) in Triton WR-1339-induced hyperlipidemic mouse model. Methods NIH mice received oral administration of different dosages of APE for 7 consecutive days. To establish hyperlipidemia mouse model, mice were injected through tail vein with Triton WR-1339 (300 mg · kg-1) on the 6th day. After 18 h,sera from all the mice were collected for measurement of total cholesterol (TC) and triglyceride (TG). In addition,the levels of malondialdehyde ( MDA ) and NO, and activities of total superoxide dismutase ( SOD ) and glutathione peroxidase (GPx) were also measured. Results Oral administration of APE at the dosage of 200 or 400 mg · kg reduced the level of MDA, but increased the level of NO, as well as the activities of SOD and GPx in serum of hyperlipidemic mice. Conclusion Treatment with APE could enhance the antioxidant ability in Triton WR-1339-induced hyperlipidemic mice.关键词
苹果多酚/Triton WR-1339/高脂血症/抗氧化Key words
apple polyphenols extract/ Triton WR-1339/ hyperlipidemia/ antioxidant分类
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胡明月,姚楠,曾晓会,黄雪君,何蓉蓉,栗原博..苹果多酚对Triton WR-1339诱发的高脂血症小鼠抗氧化能力的影响[J].广东药学院学报,2012,28(5):537-539,3.
