广东药学院学报2012，Vol.28Issue(5)：563-565,3.DOI:10.3969/j.issn.1006-8783.2012.05.025
建立小鼠深静脉血栓模型的实验研究
Establishment of deep vein thrombosis model in mice
摘要
Abstract
Objective To establish the model of deep vein thrombosis( DVT) in mice. Methods C57BL/6J mice ( n = 15) were randomly divided into the inferior vena cava ligation model group(n = 10) and sham group (n= 5 ). Inferior vena cava in mice was ligated for 48 h, and the vascular intima and thrombosis pathology were observed in the sham and DVT groups, respectively. Results Thrombosis of the inferior vena cava ligation was consistent with the pathological features of human vein thrombosis. The pathological examination showed that the vein thrombosis was full of the lumen,and no adhesion with the vascular wall. In contrast,there was no vein thrombosis in the sham control group. Conclusion The method of deep vein thrombosis in mice has been successfully established.关键词
深静脉血栓/动物模型/小鼠/下腔静脉结扎Key words
deep vein thrombosis/ animal model/ mice / inferior vena caval ligation分类
医药卫生引用本文复制引用
温定文,王丽京,李小强,朱桂平,勾红菊,方海燕,桂亚丽,吴腾,兰天,唐富天..建立小鼠深静脉血栓模型的实验研究[J].广东药学院学报,2012,28(5):563-565,3.基金项目
国家自然科学基金(30900764 （）
21005022) （）
广东省中医药局科研课题(2010198) （2010198）
