国际病理科学与临床杂志2012，Vol.32Issue(4)：320-324,5.DOI:10.3969/j.issn.1672-7347.2012.04.010
p66Shc基因表达调控及其在糖尿病肾病研究中的作用
Advancement of regulation of p66Shc expression and its role in diabetic nephropathy
摘要
Abstract
p66Shc, an adaptor protein, is known as a key regulator of cellular oxidative stress and life cycle, eventually leading to cellular oxidative injury. Diabetic nephropathy is a major cause of end-stage renal disease. Over-production of reactive oxygen species is regarded as the key process in the pathogenesis of diabetic nephropathy. In this review, we summarize the structure, function, transcription, post-translational modification to the p66Shc protein, and mitochondrial dysfunction of p66Shc gene, as well as the physiological relationships between mitochondrial dysfunction of p66Shc and reactive oxygen species, and the role of p66Shc in the pathogenesis of diabetic nephropathy.关键词
p66Shc/基因表达/氧化应激/糖尿病肾病Key words
p66Shc/ gene expression/ oxidative stress/ diabetic nephropathy引用本文复制引用
马明明,肖力,宋盼爱,刘伏友,孙林..p66Shc基因表达调控及其在糖尿病肾病研究中的作用[J].国际病理科学与临床杂志,2012,32(4):320-324,5.基金项目
国家自然科学基金(30971379) （30971379）
湖南省自然科学基金(09JJ6031). （09JJ6031）
