广西师范大学学报（自然科学版）2012，Vol.30Issue(3)：154-158,5.
基于知识粒度的不完备决策表求核方法
Algorithm for Computing Core Based on Knowledge Granulation in Incomplete Decision Table
摘要
Abstract
Abstract :HSA is a major protein component of blood plasma that has been exploited to bind and transport a wide variety of endogenous and exogenous organic compounds. While anionic drugs readily associate with the I A subdomain of HSA, most cationic drugs poorly associate to HSA at this subdomain. In this study,the association between cationic drugs and HSA by modifying HSA with fatty acid chains was improved. For our experiments,amantadine hydrochloride,a cationic drug with antiviral and antiparkin-sonian effects were tested,the results suggest that extensive myristoylation of HSA can help stabilize the interaction between amantadine and HSA in vitro. The X-ray crystallography data further elucidates the structural basis of this regulation. Additionally, the crystallography data suggests that anionic drugs, with a functional carboxylate group, may enhance the association between amantadine and HSA by a mechanism similar to myristolation- Ultimately, the results provide critical structural insight into this novel association between cationic drugs and the HSA H A subdomain,raising the tempting possibility to fully exploit the unique binding capacity of HSA's I A subdomain to achieve simultaneous delivery of anionic and cationic drugs.关键词
粗糙集/不完备决策表/知识粒度/二进制差别矩阵/求核Key words
human serum albumin/amantadine hydrochloride/fatty acid chains /fluorescence spectrum/X-ray crystallography分类
信息技术与安全科学引用本文复制引用
徐章艳,曾艳燕..基于知识粒度的不完备决策表求核方法[J].广西师范大学学报（自然科学版）,2012,30(3):154-158,5.基金项目
国家自然科学基金资助项目(60963008) （60963008）
广西自然科学基金资助项目(2011GXNSFA018163) （2011GXNSFA018163）
