河北工业科技2012，Vol.29Issue(6)：381-384,4.DOI:10.3969/j.issn.1008-1534.2012.06.009
3-噻吩丙二酸的合成研究
Synthesis of 3-thiophene malonic acid
杨英梅 1苏代国2
作者信息
- 1. 石药集团欧意药业有限公司,河北石家庄 050051
- 2. 河北科技大学体育工作部,河北石家庄050018
- 折叠
摘要
Abstract
A simple and feasible synthesis process was selected for 3-thienylmalonic acid, which is the key side-chain intermediate of semi-synthetic β-lactam antibiotic-ticarcillin sodium. The best reaction conditions of preparing 3-iodothiophene from 3-bromothiophene are as follows: the mol ratio of 3-bromothiophene to CuI is 1 : 1. 5, the concentration of the starting material is 1. 5 mol/L in quinoline, the reaction time is 20 h and the temperature is 140 ℃. The yield can be raised up to 68. 2% from 42. 0%. Its melting point is in line with the literature reported, and its structure is confirmed by infrared spectroscopy and nuclear magnetic resonance spectroscopy. The mid test yield is improved by 2. 78% contrast to small test experiment.
关键词
3-噻吩丙二酸/3-溴噻吩/3-碘代噻吩/合成Key words
3-thiophene malonic acid/ 3-bromothiophene/ 3-iodothiophene /synthesis分类
化学化工引用本文复制引用
杨英梅,苏代国..3-噻吩丙二酸的合成研究[J].河北工业科技,2012,29(6):381-384,4.
