5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究OA北大核心CSCDCSTPCD
Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model
为探讨5-氟尿嘧啶的药效、毒性与给药剂量之间的关系,采用BALB/c小鼠来源的CT26结肠癌细胞株构建小鼠结肠癌模型,分别给予10、20、30和50 mg/kg剂量的5-氟尿嘧啶,分析其抗肿瘤效果、对小鼠体质量的影响和死亡率等指标.结果表明,5-氟尿嘧啶的体内抑瘤效果及毒性与剂量密切相关.综合分析评价各指标,认为20～ 30 mg/kg剂量的5-氟尿嘧啶较适合于小鼠结肠癌模型中的药效评价.
To investigate the relationship of anticancer effects, toxicity and dose, tumor syngeneic models were made from murine colorectal adenooarcmoma cell line CT26 derived from BALB/c mice. Mice were treated with various doses (10, 20, 30 and 50 mg/kg) of 5-fluorouracil (5-FU) , and the indexes were analyzed, including the anti-tumorigenic effects, body mass and mortality of mice. The results showed that the efficacy and toxicity of 5 -FU was closely related to t…查看全部>>
唐雪莲;付京花;PARK Hyun;杨新颖
华南农业大学动物科学学院,广东广州510642华南农业大学动物科学学院,广东广州510642韩国圆光大学医学院,全罗北道益山 570749,韩国中国科学院上海药物研究所,上海201203
医药卫生
5-氟尿嘧啶药效毒性结肠癌
5-fluorouracilefficacytoxicitycolon cancer
《华南农业大学学报》 2012 (4)
维生素E对罗非鱼抗氧化功能的microRNA调控机制研究
535-538,4
The Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education,Science and Technology (2011-0020967) 国家自然科学基金(31001117)
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