华南农业大学学报2012，Vol.33Issue(4)：535-538,4.
5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究
Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model
摘要
Abstract
To investigate the relationship of anticancer effects, toxicity and dose, tumor syngeneic models were made from murine colorectal adenooarcmoma cell line CT26 derived from BALB/c mice. Mice were treated with various doses (10, 20, 30 and 50 mg/kg) of 5-fluorouracil (5-FU) , and the indexes were analyzed, including the anti-tumorigenic effects, body mass and mortality of mice. The results showed that the efficacy and toxicity of 5 -FU was closely related to the doses, and the proposal dose was 20 - 30 mg/kg which may be the optimal dose for drug research in tumor syngeneic model of mice.关键词
5-氟尿嘧啶/药效/毒性/结肠癌Key words
5-fluorouracil/efficacy/toxicity/colon cancer分类
医药卫生引用本文复制引用
唐雪莲,付京花,PARK Hyun,杨新颖..5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究[J].华南农业大学学报,2012,33(4):535-538,4.基金项目
The Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education,Science and Technology (2011-0020967) （NRF）
国家自然科学基金(31001117) （31001117）
