中医药导报2012，Vol.18Issue(9)：94-96,3.
板蓝根多糖对小鼠免疫功能的调节作用
Effect on Immunological Function of Isatis Indigotica Polysaccharide in Mice
薛瑞 1章激 1曹军华 1吴倩1
作者信息
- 1. 华中科技大学同济医学院附属襄阳医院,湖北襄阳441021
- 折叠
摘要
Abstract
Objective: To study effect on immunological function of Isatis indigotica polysaccharide (IIP) in mice. Methods: To establish an immunosuppressive mouse model by intraperitoneal injecting cyclophosphamide. Those mice were given the different doses of IIP through supplementation. The T-lymphocyte subsets were measured with staphylococcal protein A rosette test. The serum contents of IgM, IgG and IgA were determined with immunoturbidimetry. The serum content of soluble inter-leukin-2 receptor(sIL-2R) was determined with enzyme-linked immunosorbent assay. Detect the thymus index. The spleen lymphocyte proliferation and delayed type hypersensitivity were measured by MTT. Results: IIP significantly increased the percentages of CD3+ andCD4+ T-lymphocytes subsets, decreased the content of sIL-2R in mice. IIP also significantly increased the production of IgM, IgG and IgA, promoted spleen lymphocyte proliferation and delayed type hypersensitivity. Conclusion: IIP modulates the immunity in immunosuppressive model mice.关键词
板蓝根/多糖/环磷酰胺/免疫Key words
Isatis Indigotica/ Polysaccharids/ Cyclophosphamide/ Immunity分类
医药卫生引用本文复制引用
薛瑞,章激,曹军华,吴倩..板蓝根多糖对小鼠免疫功能的调节作用[J].中医药导报,2012,18(9):94-96,3.
