化学工程2012，Vol.40Issue(11)：17-21,5.DOI:10.3969/j.issn.1005-9954.2012.11.005
必特螺旋霉素萃取过程研究
Extraction process of bitespiramycin
摘要
Abstract
The effects of temperature, pH and mass fraction of NaH2PO4 on the solubility of bitespiramycin in the different solvent systems were researched from the view of thermodynamics. The extraction technology characteristics of bitespiramycin from petroleum ether eluent with phosphates buffer solution were studied. The influences of temperature, pH and mass fraction of NaH2PO4 on the extraction process and extraction distribution coefficient α were studied. H3PO4-0. 7% NaH2PO4( mass fraction ) buffer solution was chosen as the extraction agent in the extraction experiments with phase ratio A/0 = 1/10. It shows that the optimum pH range is 2.0-2.2 for extraction process, and the distribution coefficient a decreases with temperature rise. The extraction process is exothermic process. Low temperature and high mass fraction of NaH2PO4 are conducive to the promotion of extraction yield. Based on the experimental results, the extraction distribution coefficient theoretical models of a-pH and a-T were developed, and the mathematical formula α-pH-T was derived with software Matlab.关键词
必特螺旋霉素/萃取/溶解度/分配系数Key words
bitespiramycin/ extraction/ solubility/ distribution coefficient分类
化学化工引用本文复制引用
岳公敬,朱家文,陈葵,徐婕,张优利..必特螺旋霉素萃取过程研究[J].化学工程,2012,40(11):17-21,5.基金项目
上海市科委生物医药重点科技攻关项目(10431901500) （10431901500）
