解剖学杂志2012，Vol.35Issue(3)：319-321,3.
白藜芦醇诱导大鼠肝癌细胞凋亡的作用
Effects of resveratrol on apoptosis in rat hepatoma cells CBRH7919
摘要
Abstract
Objective:To explore the effect of resveratrol (Res) on rat hepatoma cells CBRH7919 and the mechanism underlying this effect. Methods-, The cell viability and growth of CBRH7919 cultured with different doses of Res was detected by SRB method. The changes of cell cycle, cell apototis and mitochondrial membrane potential were determined by flow cytom-etry. Results:The inhibition of Res on cell viability of CBRH7919 had time-dependent and dose-dependent manners. After being treated with Res, the apoptosis of CBRH7919 was increased, and the cell number of CBRH7919 in G0-G1 phase was increased and the mitochondrial membrane potential of CBRH-7919 cells was decreased. Conclusion:Res has an inhibitory effect on the cell growth of CBRH7919 cells through the mitochondrial membrane pathway.关键词
白藜芦醇/大鼠肝癌细胞CBRH7919/细胞凋亡/细胞周期/线粒体膜电位Key words
resveratrol/ rat hepatoma cells CBRH7919/ apoptosis/ cell cycle/ mitochondrial membrane potential引用本文复制引用
魏光成,闫苗苗,徐爱丽,马朋,张丽霞,于敏..白藜芦醇诱导大鼠肝癌细胞凋亡的作用[J].解剖学杂志,2012,35(3):319-321,3.基金项目
山东省高校科技计划(J09LC66) （J09LC66）
山东省自然科学基金(ZR2010BL026) （ZR2010BL026）
