解剖学杂志2012，Vol.35Issue(3)：341-344,4.
黄芩茎叶总黄酮预处理对局灶性脑缺血再灌注大鼠海马神经元和血脑屏障形态学的影响
Effect of pretreatment with scutellaria baicalensis stem-leaf total flavonoid on morphologic changes of hippocampus neurons and blood brain barrier followed by focal cerebral ischemia reperfusion in rats
摘要
Abstract
Objective:To study the influence of scutellaria baicalensis stem-leaf total flavonoid (SSTF) on the morphologic changes of hippocampus neurons and blood brain barrier (BBB) induced by focal cerebral ischemia reperfusion in rats. Methods:50 SD rats were randomly divided into five groups: sham operation group, ischemia reperfusion group. SSTF pretreatment groups (SSTF 50 mg o kg-1 , 100 mg o kg-1 and 200 mg o kg-1 , respectively). The model of focal ischemia reperfusion in rats was established with suture occluded method invented by Zea Longa and improved properly in our lab. The changes of the neurological function, neuron density in hippocampus CA1 were measured 24 hours after cerebral ischemia reperfusion. The ultrastructure changes of hippocampus neurons and BBB in each group were observed under a transmission electron microscope. Results:SSTF pretreatment improved rats neurological behavior. Compared with I/R group, SSTF markedly induced the increase of survival pyramidal cells in the hippocampus CAl region, significantly improved the morphologic changes of hippocampus neurons and BBB and presented a dose dependence effective relations. Conclusion :SSTF pretreatment has an obviously protective effect on the morphologic changes of hippocampus neurons and BBB induced by focal cerebral ischemia in rats.关键词
黄芩茎叶总黄酮/预处理/缺血再灌注/海马/超微结构/血脑屏障Key words
scutellaria baicalensis stem-leaf total flavonoid/ pretreatment/ ischemia reperfusion/ hippocampus/ ultrastructure/ blood brain barrier引用本文复制引用
陈萌,孔维,赵淑敏,张树峰,孔祥玉,李涵,郑小影..黄芩茎叶总黄酮预处理对局灶性脑缺血再灌注大鼠海马神经元和血脑屏障形态学的影响[J].解剖学杂志,2012,35(3):341-344,4.基金项目
河北省科技厅,河北省教育厅资助课题(07276101D-46,2005227) （07276101D-46,2005227）
