解剖学杂志2012，Vol.35Issue(4)：476-480,492,6.
大鼠脊髓损伤后不同时间点5-HT2A受体免疫反应性的变化
Changes of serotonin 2a receptor immunoreactivity after rat spinal cord transection at different time
王永为 1陈萌 1孔祥玉1
作者信息
- 1. 承德医学院脊髓损伤与修复研究室,承德067000
- 折叠
摘要
Abstract
Objective:To explore the changes of serotonin 2a (5-HT2A) receptor immunoreacitivity following chronic spinal transection at S2. Methods:Wistar rats were randomly divided into 7 groups: 2h, 8h, 1d, 2d, 7d, 30d and 60d groups. And, animals in each group were subdivided into sham and operated groups. In operated group, the spinal cord was transected completely at S2, while the only the second lumbar vertebral lamina was removed but the dura was kept intact in sham animals. Then, expression of 5-HT2A receptor below the lesion of the spinal cord was detected immunohistochemically. Results:Compared with those in sham animals, the immunoreactivity of 5-HT2A receptor in model animals were comparable to sham at postoperative hour 2 and 8, and increased gradually and peaked at postoperative day 60. Conclusion: The upregula-tion of 5-HT2A receptor may underlay the supersensitivity of spinal motor neurons by 5-HT denervatton and spasticity after a complete chronic transection of the spinal cord.关键词
脊髓损伤/5-羟色胺2A受体/超敏感性反应/痉挛状态Key words
spinal cord injury/ serotonin 2a receptor/ supersensitivity/ spasticity引用本文复制引用
王永为,陈萌,孔祥玉..大鼠脊髓损伤后不同时间点5-HT2A受体免疫反应性的变化[J].解剖学杂志,2012,35(4):476-480,492,6.
