解剖学杂志2012，Vol.35Issue(4)：485-488,4.
糖尿病大鼠穹窿下器室管膜细胞的形态学变化
Morphological changes of ependymal cells in subfornical organ of diabetic rat
摘要
Abstract
Objective:To observe the morphological changes in ependymal cells of subfornical organ (SFO) in different stages of diabetic rat. Methods: Each healthy male Wistar rat was given the streptozotocin (STZ) 60 mg/kg to establish a model of type I diabetes. Then the rats were randomly divided into three groups: 2-week group, 4-week group and 8-week group. Scanning electron microscopy and transmission electron microscopy were used to observe the morphological changes of subfornical organ ependymal cells at different times. Results: Ependymal cells were bulging and surface was smooth, with limpid microvilli in the control group; The cells were tumbling, thin and flat, and small round holes were breaking on the cell surface in 2-week treatment group; Ependymal cell surface was uneven, line of dependency appeared, and the cell membrane showed multiple small break holes, which were found lack of visible membrane and organelles exposed cells in 4-week treatment group; Ependymal cell surface folded obviously, and showed a large number of spherical secretory granules in 8-week treatment group. The ependymal cell had a complete surface of cerebral ventricles, and there were sparing microvilli and corpora mammillaria microapophysis in the control group; Ependymal surface showed a large number of secretory granules in the model group. Conclusion: The diabetes can cause damage of SFO ependymal cells in Wistar rats and large amounts of secretory granules.关键词
糖尿病/穹窿下器/室管膜细胞/大鼠Key words
diabetes/ subfornical organ/ ependymal cell/ rat引用本文复制引用
唐蔚东,马常升,郝庆卯,叶建亚,张志琴,李彩格..糖尿病大鼠穹窿下器室管膜细胞的形态学变化[J].解剖学杂志,2012,35(4):485-488,4.基金项目
河北省自然科学基金(G2005000724) （G2005000724）
河北省自然科学基金(302491) （302491）
河北省卫生厅医学科学研究重点资助课题(20100032) （20100032）
