解剖学杂志2012，Vol.35Issue(5)：571-574,4.DOI:10.3969/j.issn.1001-1633.2012.05.005
胎儿睾丸发生过程中转化生长因子β1与Smad4的表达
Expression of TGF-β1 and Smad4 during the development of human fetal testis
摘要
Abstract
Objective:To observe the expression features of TGF-β1 and Smad4 and study their roles during the development of the human fetal testis. Methods: The positive rates of TGF-β1 and Smad4 in the testis between different human fetal ages were examined by HE staining and SP immunohistochemical technique. Results: The expressions of TGF-β1 and Smad4 at different degrees were found in Leydig cells and Germ cells. TGF-β1 expression reached its peak from the 12th to 20th week and Smad4 expression reached its peak from 12th to 24th week. 24 weeks later, the number of positive cells decreased gradually with increasing of the fetal ages. Conclusion: The expressions of TGF-β1 and Smad4 in different degrees are found during the development of human fetal testis, which indicates that they have important roles during the testis development.关键词
转化生长因子β1/Smad4/睾丸/免疫组织化学/胚胎Key words
transforming growth factor-β1/ Smad4/testis/ immunohistochemistry/ fetus引用本文复制引用
艾庆燕,赵豫凤,杨加周,王艳梅,米志宽,苗乃周..胎儿睾丸发生过程中转化生长因子β1与Smad4的表达[J].解剖学杂志,2012,35(5):571-574,4.基金项目
陕西省科技厅自然科学基础项目(2010JM4024) （2010JM4024）
陕西省教育厅科研项目(2010JK907) （2010JK907）
延安市科技项目(2011ks-19) （2011ks-19）
