实用临床医药杂志2012，Vol.16Issue(15)：5-7,3.
内皮型氧化亚氮合酶基因G894T、胰岛素受体基因第17外显子多态性与老年痴呆的关系研究
Relationship between polymorphism of insulin receptor gene exon 17, endothelial nitric oxide synthase gene G894T and Alzheimer's disease
摘要
Abstract
Objective To study the relationship between polymorphism of insulin receptor gene exon 17,endothelial nitric oxide synthase gene G894T and Alzheimer's disease. Methods A total of 100 patients with Alzheimer's disease (AD) and vascular dementia (VaD) in our hospital were selected and divided into AD group (n = 50) and VaD group (n = 50). Another 50 healthy subjects were selected as control group. They were subjected to drawing blood of 5 mL with an empty stomach in the morning,and the DNA was extracted from blood cells. The polymorphism of insulin receptor gene exon 17 and endothelial nitric oxide synthase gene G894T were analyzed. Results There were statistically significant differences in the GG,GT and TT genotype distribution frequency between the AD group,the VaD group and the control group. The INSR T- allele frequency in the AD group was higher than that in the control group,but the difference was not significant (P >0. 05). The INSR T - allele frequency in the VAD group was significantly higher than that in the control group. Conclusion The polymorphism of insulin receptor gene exon 17 and endothelial nitric oxide synthase gene G894T are correlated with Alzheimer's disease and vascular dementia. AD and VaD have the same genetic risk factors.关键词
内皮型氧化亚氮合酶基因G894T多态性/胰岛素受体基因第17外显子多态性/老年痴呆Key words
polymorphism of endothelial nitric oxide synthase gene G894T/polymorphism of insulin receptor gene exon 17/Alzheimer s disease分类
医药卫生引用本文复制引用
周伟宏,吴永华..内皮型氧化亚氮合酶基因G894T、胰岛素受体基因第17外显子多态性与老年痴呆的关系研究[J].实用临床医药杂志,2012,16(15):5-7,3.基金项目
中国高校医学期刊临床专项资金(11220090) （11220090）
