实用临床医药杂志2012，Vol.16Issue(15)：41-43,3.
辛伐他汀对尿毒症非透析患者血清白介素-6、C反应蛋白和营养学指标的影响
Influence of simavastatin on interleukin- 6, C- reactive protein and nutrition indicators in uremia patients without dialysis
摘要
Abstract
Objective To investigate the influence of simavastatin on microinflammation and nutrition indicators in uremia patients without dialysis. Methods Eighty -six uremia patients witout dialysis from our hospital were randomly divided into statin treatment group and control group. The changes of C- reactive protein (CRP),interleukin- 6 (IL - 6) and nutrition indicators were monitored before and after treatment. Results Compared with the control group,the levels of CRP and IL - 6 of the statin treatment group were significantly increased,while plasma albumin (ALB) and hemoglobin (Hb) were significantly decreased. 24 weeks after treatment,the levels of CRP,IL-6,serum creatinine (Scr) and blood urea nitrogen (BUN) of the statin treatment group were significantly decreased,while the levels of Alb and Hb were significantly increased. Compared with the pre- treatment and control group,the difference was statistically significant. Meanwhile Alb,Hb and Ccr in the control group showed a downward trend. There were no significant changes in the two groups in terms of creatinine clearance. Conclusion Simvastatin treatment can inhibit the micro- inflammatory response of the uremic non- dialysis and improve nutritional status.关键词
辛伐他汀/尿毒症/微炎症反应/营养学指标Key words
simvastatin/uremia/micro - inflammatory response/nutrition indicators分类
医药卫生引用本文复制引用
吴秀芝..辛伐他汀对尿毒症非透析患者血清白介素-6、C反应蛋白和营养学指标的影响[J].实用临床医药杂志,2012,16(15):41-43,3.基金项目
中国高校医学期刊临床专项资金(1220096) （1220096）
