实用临床医药杂志2012，Vol.16Issue(17)：5-6,14,3.
神经生长因子对大鼠脑缺血再灌注损伤的神经保护
Neuroprotective effects of nerve growth factor on ischemia-referfusion injury in rats
汪志峰 1张毅 2马宝君 3虞昊3
作者信息
- 1. 南通大学第二附属医院神经外科,江苏南通,226001
- 2. 南通大学第二附属医院心胸外科,江苏南通,226001
- 折叠
摘要
Abstract
Objective To explore the protective effects of nerve growth factor on focal cerebral ischemia-reperfusion injury in rats. Methods Thread embolism was performed to establish focal cerebral ischemia-reperfusion model in rates. After treatment of NGF, TNF-α, IL-1, IL-6, MDA and SOD content were measured, and cortical neurons apoptosis were detected by TUNEL. Results Compared with IR group, TNF-α, IL-1β of NGF groups decreased significantly, and SOD activity of NGF groups increased significantly. MDA and IL-6 in NGF groups decreased significantly. Cerebral cortex neural cell apoptosis detected that apoptosis cells in NGF group significantly reduced compared to the IR group. Conclusion In the rats with a focal ischemia-reperfusion injury, nerve growth factor has significant neuroprotective effects. NGF can reduce the inflammatory response, improve the metabolism of oxygen free radieals and reduce the apoptosis of brain cell.
关键词
神经生长因子/缺血再灌注损伤/脑保护/炎症因子/凋亡Key words
nerve growth factor/ ischemic postconditioning/ cerebral protection/ inflammatory cytokines/ apoptosis
分类
医药卫生引用本文复制引用
汪志峰,张毅,马宝君,虞昊..神经生长因子对大鼠脑缺血再灌注损伤的神经保护[J].实用临床医药杂志,2012,16(17):5-6,14,3.
