实用临床医药杂志2012，Vol.16Issue(17)：15-17,24,4.
Periostin基因多态性与苏皖汉族人群冠心病发病的初步研究
Preliminary research on Periostin gene polymorphisms and incidence of coronary artery disease in Han nationality of Jiangsu and Anhui provinces
周学军 1纪元 1蒋建光 1刘志平 1王芳芳 1丁志坚1
作者信息
- 1. 南京医科大学附属常州第二人民医院心内科,江苏常州,213000
- 折叠
摘要
Abstract
Objective To explore whether the polymorphisms in Periostin (POSTN) are associated with the risk of coronary artery disease ( CAD ) . Methods The single nucleotide polymorphisms (SNP A-953T) within the promoter region were chosen for further analyses. The possible relationship between POSTN gene polymorphisms and incidence of coronary artery disease were observed. Results In our study, the TT genotype of SNP-A953T was first detected to be valid in the Chinese population, not available in the HAPMAP CHB Project. For the A953T polymorphism, of the 554 cases, 275 homozygotes for the A allele, 202 heterozygotes and 16 homozygotes for the T allele were detected , of the 687 controls, 368" homozygotes for the A allele, 266 heterozygotes and 31 homozygotes for the T allele were detected. Genotype distribution of the POSTN was not found to differ significantly in CAD subjects when compared to controls. Conclusion POSTN polymorphisms SNPA -953T are not significantly associated with the risk of CAD in Chinese population of our study.
关键词
冠心病/Periostin基因/单核苷酸多态性/血浆Key words
coronary artery disease/ periostin/ single nucleotide polymorphism/ plasma分类
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周学军,纪元,蒋建光,刘志平,王芳芳,丁志坚..Periostin基因多态性与苏皖汉族人群冠心病发病的初步研究[J].实用临床医药杂志,2012,16(17):15-17,24,4.
