实用临床医药杂志2012，Vol.16Issue(17)：40-42,3.
不同剂量脑预防照射对局限期小细胞肺癌患者的临床观察
Clinical observation of different doses of brain prophylactic irradiation for limited stage small cell lung cancer
摘要
Abstract
Objective To observe the impact of different doses of prophylactic cranial irradiation (PCI) to brain metastasis and survival rate for limited stage small cell lung cancer (LSS-CLC). Methods Eighty-four LSSCLC patients admitted to our hospital were randomized into standard-dose PCI group, higher-dose PCI group and control group. The incidence of brain metastasis, overall survival rate, as well as the adverse reactions caused by irradiative brain injury over a two-year period were observed. Results The incidence rates of two-year brain metastases in the standard -dose PCI group and the higher-dose PCI group showed no statistically significant difference. The median survival period of brain metastases patients and brain metastases patients was 17. 6 months and 47.4 months, respectively. One-year and three-year survival rates of the standard-dose group were higher than the higher-dose group, but the difference was not significant. Conclusion After LSSCLC surgery and chemotherapy or radiotherapy and chemotherapy, prophylactic cranial irradiation can reduce the incidence rate of brain metastases. 25 Gy of PCI should remain the standard treatment dose for LSSCLS.关键词
小细胞肺癌/局限期/预防性全脑照射/脑转移/生存率Key words
small cell lung cancer/ limited stage/ prophylactic cranial irradiation/ brain metastases/ survival rate分类
医药卫生引用本文复制引用
郑晓丽,杨成梁,葛红..不同剂量脑预防照射对局限期小细胞肺癌患者的临床观察[J].实用临床医药杂志,2012,16(17):40-42,3.基金项目
中国高校医学期刊临床专项资金(11220116) （11220116）
