实用临床医药杂志2012，Vol.16Issue(19)：19-22,4.
基因OCT4、CD133在非小细胞肺癌组织中的表达及临床意义
Expression and significance of OCT4 , CD133 in non-small cell lung cancer
摘要
Abstract
Objective To compare the expressions of 0CT4 and CD133 in non-small cell lung cancer (NSCLC) , adjacent tissues and normal lung tissues, and to evaluate the relationship between the expression and clinical characteristics. Methods Fifty NSCLC tissues, 20 adjacent tissues and normal lung tissues respectively were randomly selected. Immunohistochemical staining was used to detect the expressions of OCT4 and CD]33. The relationship between the expression and clinical characteristics were analyzed. Results The positive rates of OCT4 and CD133 in adjacent tissues and normal lung tissues were significantly lower than that in NSCLC tissue. The positive rates of OCT4 in poorly and undifferentiated tissues were significantly higher than that in well and moderately differentiated tissues. The positive rates of OCT4 and CD133 in the cases with distant metastasis were significantly higher than that without distant metastasis. There were 15 cases with positive OCT4 and CD133, and 12 cases with negative ones. The expressions of them were positively correlated (P = 0. 0218) . Conclusion OCT4 and CD133 probably play an important role in the process of transformation of the normal cell to malignant cells. To detect the expression of OCT4 and CD133 may help in the early diagnosis of the lung cancer, and may provide the theory basis of confirmation or differentiation of tumor stem cells markers and target therapy of cancer stem cells.关键词
非小细胞肺癌/肿瘤干细胞/OCT4/CD133/免疫组化Key words
non-small cell lung cancer/ cancer stem cells/ OCT4 / CD133/ immunohistochemical分类
医药卫生引用本文复制引用
倪静怡,杨磊,朱兴华,茅国新..基因OCT4、CD133在非小细胞肺癌组织中的表达及临床意义[J].实用临床医药杂志,2012,16(19):19-22,4.基金项目
中国高校医学期刊临床专项资金(11220173) （11220173）
