实用临床医药杂志2012，Vol.16Issue(19)：43-45,51,4.
国产盐酸帕洛诺司琼注射液预防化疗所致恶心呕吐的随机对照研究
Randomized controlled study on efficacy and safety of domestic palonosetron hydrochloride in prevention of nausea and vomiting induced by chemotherapy
陈艳1
作者信息
- 1. 江苏省盐城市第一人民医院,江苏盐城,224000
- 折叠
摘要
Abstract
Objective To assess the efficacy and safety of palonosctron for preventing nause-a and vomiting caused by high emetic risk chemotherapy. Methods Malignant patients who were accord with the standard were assigned to groups AB and BA randomly to receive a single dose of palonosetron or tropisetron 30 min before chemotherapy. The nausea and vomiting episodes and adverse effects within 5 days after chemotherapy were observed. Results A total of 24 patients were enrolled and only 18 patients could be evaluated. The complete control rates and efficacy control rates of acute nausea, delayed nausea, acute vomiting, and the complete control rate of delayed vomiting showed no significant differences. The efficacy control rate of delayed vomiting with palonosetron was obviously higher than that with tropisetron. The adverse reactions of the two drugs were fewer and mild without statistic difference. Conclusion For high emetic risk chemotherapy, palonosetron is similar to tropisetron for preventing nausea and acute vomiting. But it is superior to tropisetron for preventing delayed vomiting with fewer and mild side effects.
关键词
帕洛诺司琼/托烷司琼/化疗/恶心/呕吐Key words
palonosetron/ tropisetron/ chemotherapy/ nausea/ vomiting分类
医药卫生引用本文复制引用
陈艳..国产盐酸帕洛诺司琼注射液预防化疗所致恶心呕吐的随机对照研究[J].实用临床医药杂志,2012,16(19):43-45,51,4.
