实用临床医药杂志2012，Vol.16Issue(19)：46-48,3.
化疗对晚期肺癌患者凝血、纤溶系统影响的临床研究
Influence of chemotherapy on coagulation and fibrinolysis system in patients with advanced lung cancer
薛英波 1倪婷婷 1俞婕 1李杭1
作者信息
- 1. 贵州省人民医院肿瘤科,贵州贵阳,550002
- 折叠
摘要
Abstract
Objective To evaluate the variation and meaning of coagulation index before and after chemotherapy in patients with advanced lung cancer. Methods The plasma levels of pro-thrombin time (PT), fibrinogen (Fbg), activated partial thromboplastin time (APTT), thrombin time (TT) and D-dimer (D-D) were tested in 50 patients with advanced lung cancer (lung cancer group) and compared with 30 healthy adults (control group). Results Compared with the control group, the mean values of APTT, TT in lung cancer group were significantly shorter, and the Fbg, D-D were significantly higher (P<0.01). Compared with pre-chemotherapy, the PT in lung cancer group post-chemotherapy was longer, the APTT, TT were shorter, and the Fbg, D-D were higher (P<0.05 or P<0.01). Conclusion Chemotherapy may exacerbate the release of coagulation factors and inhibition state of fibrinolysis system, which results in abnormal coagulation in advanced lung cancer.
关键词
肺肿瘤/化疗/凝血指标/纤溶功能Key words
lung cancer/ chemotherapy/ coagulayion index分类
医药卫生引用本文复制引用
薛英波,倪婷婷,俞婕,李杭..化疗对晚期肺癌患者凝血、纤溶系统影响的临床研究[J].实用临床医药杂志,2012,16(19):46-48,3.
