实用临床医药杂志2012，Vol.16Issue(19)：99-101,3.
雷替曲塞与卡培他滨联合奥沙利铂治疗老年晚期结直肠癌的疗效比较
Comparison of the combined raltitrexed-oxaliplatin and combined xeloda-oxaliplatin in the treatment of senile advanced colorectal carcinoma
摘要
Abstract
Objective To observe the efficacy and safety of the combined raltitrexed-oxali-platin and xeloda-oxaliplatin in the treatment of senile advanced colorectal carcinoma. Methods Sixty-four advanced colorectal cancer patients were divided into two groups. The treatment group (n = 33) was administered intravenously raltitrexed 15 min drip with 3 mg/m , oxaliplatin 3-hour drip with 130 mg/m2 on day 1. The control group ( n = 31) was administered capecitabine 1000 mg/m2, orally 2 times/day, the first one to 14 days, oxaliplatin 3-hour drip with 130 mg/m on day 1. Results A total of 32 patients in the treatment group and 30 patients in the control group were evaluated. Effective rates were 49. 2% and 47. 9% , respectively. Median 1TP were 8. 2 and 7. 9 months, respectively. No significant statistical difference was found in the short-term efficacies of the two groups (P > 0. 05). Adverse reactions compared to the elevated transaminase enzymes in the treatment group was higher than that in the control group; There were more patients who developed tiredness and reduced neutropenia in the treatment group (P<0.05). There were more patients who developed hand - foot syndrome and vomiting in the control group (P<0.05). Conclusion The combined raltitrexed-oxaliplatinl has similar efficacy with that of XELOX. But it is more convenient and safer.关键词
雷替曲塞/卡培他滨/奥沙利铂/晚期结直肠癌Key words
raltitrexed/ xeloda/ oxaliplatin/ advanced colorectal carcinoma分类
医药卫生引用本文复制引用
张蓓..雷替曲塞与卡培他滨联合奥沙利铂治疗老年晚期结直肠癌的疗效比较[J].实用临床医药杂志,2012,16(19):99-101,3.基金项目
中国高校医学期刊临床专项资金(11220178) （11220178）
