实用临床医药杂志2012，Vol.16Issue(19)：167-168,170,3.
可透过血脑屏障的MRI造影剂的实验研究
An empirical study on MRI contrast agents passing through the blood brain barrier
摘要
Abstract
Objective To develop a kind of contrast agent which can pass through blood brain barrier for MRI use, and to form a base to further develop the special targeted inner-brain molecular probe. Methods The mixture of FC3O4 nanoparticles packed by polysorbate80 was injected into 20 New Zealand rabbits. Results MRI scanning was carried out 5 min, 10 min and 30 min after the injection. The T2WI showed that the signal of the brain essence of the 20 rabbits dropped gradually with time passing by. And 12 hours later, the signal dropped significantly.Conclusion Fe3O4 nanoparticles packed by polysorbate 80 is an ideal arid practical contrast agent which can pass through blood brain barrier for MRI use. This contrast agent can be used to develop the targeted inner-brain molecular probes.关键词
分子探针/聚山梨酯/磁共振成像/造影剂Key words
molecular probe/ polysorbate/ magnetic resonance imaging/ contrast agents分类
医药卫生引用本文复制引用
仲阳,张本善,白卓杰,孙晓东,王小进,陈会进..可透过血脑屏障的MRI造影剂的实验研究[J].实用临床医药杂志,2012,16(19):167-168,170,3.基金项目
南京市医学科技发展基金资助课题(YKK08144) （YKK08144）
