军事医学2012，Vol.36Issue(11)：830-834,5.
结合RNA的蛋白质位点预测研究
Prediction of RNA-binding residues in protein sequence
摘要
Abstract
Objective To develop mathematical models for detecting RNA-binding residues. Methods Totally 532 protein-RNA complexes from the Protein Data Bank were extracted, and 150 features were calculated for each interacting or non-interacting residue. Then, two RNA-binding site prediction models were developed using machine learning methods. Results Test results showed that the two models had better performance than previous ones on the same dataset. Conclusion This work provides a better bioinformatics support for searching for RNA-binding residues in protein sequence.关键词
蛋白质-RNA复合物/结合位点/预测模型Key words
protein-RNA complex/ binding sites/ prediction model分类
生物科学引用本文复制引用
查磊,应晓敏,李伍举..结合RNA的蛋白质位点预测研究[J].军事医学,2012,36(11):830-834,5.基金项目
国家973计划资助项目(2010CB912801) （2010CB912801）
国家自然科学基金资助项目(31071157) （31071157）
