军事医学2012，Vol.36Issue(11)：855-857,3.
党参乙醇总提物的抗辐射作用研究
Antiradiation effect of total ethanol extract from Codonopsis pilosula
孔祥娟 1王升启2
作者信息
- 1. 天津中医药大学研究生学院,天津,300193
- 2. 军事医学科学院放射与辐射医学研究所,北京,100850
- 折叠
摘要
Abstract
Objective To explore the antiradiation effect of total ethanol extract from Codonopsis pilosula ( Franch. ) Nannf. ( TEC ) in mice. Methods Seventy mice were irradiated by 7. 5 Gy60 Co γ-rays once before or after application of two different doses of TEC or normal saline for the control group. The difference in survival rates and changes in blood cells were observed in order to choose the better drug delⅣery. The other 40 mice were irradiated with 8. 0 Gy 60Co γ-rays and their mortality and average survival days were calculated. Results ( 1 ) When the drug was given before injury, the survival rate, average survival days, WBC and PLT counts of the radiation injured mice were increased obviously. ( 2 )When given after injury, neither dose produced any effect. ( 3 )The 30-day survⅣal rate and average survival days were much better than those of the control group when irradiated with 8. 0 Gy 60Co γ-rays. Conclusion TEC has significant antiradiation effect and can effectively raise the survival rate of mice irradiated with a lethal dose of Co γ-rays. It can also reduce the injury of radiation to WBC and PLT in mice.关键词
党参/辐射损伤/辐射防护Key words
Codonopsis pilosula/ radiation injury/ radioprotection 分类
医药卫生引用本文复制引用
孔祥娟,王升启..党参乙醇总提物的抗辐射作用研究[J].军事医学,2012,36(11):855-857,3.
