昆明医学院学报2012，Vol.33Issue(8)：17-20,4.
急性甲醇中毒大鼠空间学习记忆功能改变的研究
A Study on the Spatial Learning and Memory Ability after Acute Methanol Poisoning in Rats
摘要
Abstract
Objective To study the change of spatial learning and memory fuction in rats induced by acute methanol poisoning. Methods Animal model of methanol poisoning was made, and rats received normal saline were selected as control. The rats were placed in a plexiglas chamber that exposed to a mixture of N2O/O2 and gaved different dosage of methanol by gavage. The spatial learning and memory ability was assessed with Morris Water Maze. Results Compared with the control group (60.43 ±7.13) s, the performance latency on the Morris Water Maze prolonged in low dosage group (89.55 ± 7.98) s and high dosage group (98.77 ± 5.64) s rats on the first day post-injury. The latency in high dosage group was much longer than that in low dosage group and control group on the 2nd~5th day post-injury (P<0.05). There were no statistical differences among three groups during the visible platform tests and probe tests. Conclusion Rats subjected to acute methanol poisoning have spatial learning and memory function dysfunction and, in this connection, the degree of poisoning and the dose administered is apparently related.关键词
甲醇中毒/大鼠/空间学习记忆/Morris水迷宫Key words
Methanol poisoning/Rat/Spatial learning and memory/Morris water maze分类
医药卫生引用本文复制引用
童宗武,苏少明,周卫敏,杨崇猛,夏青青,袁云,杨力,吴春云..急性甲醇中毒大鼠空间学习记忆功能改变的研究[J].昆明医学院学报,2012,33(8):17-20,4.基金项目
国家自然科学基金资助项目(30900778) （30900778）
云南省应用基础研究基金资助项目(2009ZC097M) （2009ZC097M）
