口腔颌面外科杂志2012，Vol.22Issue(5)：350-353,4.DOI:10.3969/j.issn.1005-4979.2012.05.010
口腔鳞状细胞癌中S100A4蛋白、MMP-2蛋白的表达及意义
Significance of S100A4 and MMP-2 Expression in Oral Squamous Cell
关键 1张洪凯 1段峰 1张国梁 1王心彧1
作者信息
- 1. 佳木斯大学口腔医学院口腔颌面外科,黑龙江佳木斯 154002
- 折叠
摘要
Abstract
Objective: To evaluate the clinical significance on the expression of S100A4 and MMP-2 in oral squanous cell carcinoma (OSCC). Methods: In 40 pathological diagnosed OSCC cases, S100A4 and MMP-2 were detected by immunohistochemical SP method. Normal oral mucosa was used as control. Result: CD Expression intensity of S100A4 in OSCC was not obviously related with the age, gender, tumor size,TNM clinical stage and pathological grade (P>0.05). But expression rate of S100A4 in OSCC was positively correlated with lymph node metastasis (P<0.05). (2) Expression of MMP-2 was not obviously related with the age, gender, tumor size and pathological grade(P>0.05). The expression rate of MMP-2 in OSCC was positively correlated with lymph node metastasis (P<0.05). In OSCC, protein expression of S100A4 and MMP-2 were positively coreelated. Conclusion: These genes and protein products may be served as a potential diagnostic targets in tumor metastasis.关键词
口腔鳞状细胞癌/MMP-2/S100A4Key words
oral squamous cell carcinoma(OSCC)/ MMP-2 / S100A4分类
医药卫生引用本文复制引用
关键,张洪凯,段峰,张国梁,王心彧..口腔鳞状细胞癌中S100A4蛋白、MMP-2蛋白的表达及意义[J].口腔颌面外科杂志,2012,22(5):350-353,4.
