临床与实验病理学杂志2012，Vol.28Issue(10)：1112-1115,4.
子宫颈癌中Smad4和Runx3表达与HPV16感染的关系
Expression of Smad4 and Runx3 in cervical lesions and their association with HPV16 infection
摘要
Abstract
Purpose To explore the expression of Smad4 and R nnx3 in cervical lesions, and to investigate their association with HPV 16 infection. Methods Immounohistochemistry was performed to detect the expression of Smad4 and Rnnx3 protein in formal in-fixed and paraffin-embedded cervical tissue specimens with cervicitis,cervical intraepithelial neoplasia ( CIN ) and cervical sqiiamonse cell carci-nania ( CSCC ). The HPV16 DNA was detected by PCR. Results The positive expression rates of Smad4 and Riinx3 in chronical cervicitis, CIN and cervical cancer were 80% and 69. 8% ,40% and 84% , and 69. 8% and 40% , respectively. The expression of Smad4 and Rimx3 was higher in cervicitis than that in CIN and cervical cancer ( P ＜0. 05 ). The expresssion of Smad4 was related to the tumor differentiation and lymph node metastasis. The lower expresssion of Rnnx3 was not only correlated with the tumor differentiation and and lymph node metastasis, but also significantly related to FIGOs' stages ( P ＜0. 05 ). But Smad4 was negatively associated with HPV 16 infection in CSCC ( r = -0. 327 , P ＜0. 05 ). Conclusion Decreased expression of Rnnx3 and down-regidation of Smad4 by HPV 16 infection in CIN and CSCC are important factors blocking TGF/Smads signal pathway, and might be related to the pathogen-esis and progression of cervical lesions.关键词
子宫颈肿瘤/Smad4/Runx3/HPV16Key words
cervix neoplasms/ Smad4/ Rnnx3/ HPV16分类
医药卫生引用本文复制引用
李巧稚,阿提开姆·阿布都克热木,王燕,程杰,阿布力孜·阿布杜拉..子宫颈癌中Smad4和Runx3表达与HPV16感染的关系[J].临床与实验病理学杂志,2012,28(10):1112-1115,4.基金项目
新疆维吾尔自治区自然科学基金(2012211B10) （2012211B10）
