南京医科大学学报（自然科学版）2012，Vol.32Issue(10)：1401-1404,4.
血小板参数与2型糖尿病患者微量白蛋白尿及外周血管病变的关系
Relationship between platelet parameters and albuminuria and peripheral vascular complications of type 2 diabetes patients
杨俊 1肖文金 2胡吉 2董吉祥 2黄韵 2张笑燕2
作者信息
- 1. 江苏省省机关医院内分泌科,江苏南京210024
- 2. 苏州大学附属第二医院内分泌科,江苏苏州215004
- 折叠
摘要
Abstract
Objective:To explore the relationship between platelet parameters and microangiopathy and peripheral arterial disease(PAD)in type 2 diabetes. Methods: Total 650 patients with type 2 diabetes were collected. The levels of platelet count(PLT),mean platelet volume(MPV),platelet distribution width(PDW),clinical and biochemical characteristics,microalbuminuria(MAU)and ankle brachial index(ABI)were measured. The patients were divided into MAU group and normal abuminuria group according to presence or absence of MAU. The patients were also divided into PAD group and non-PAD group according to the ABI value. The comparison of platelet parameters and biochemical indices between groups was performed. The correlation of the risk factors for MAU and PAD were analyzed. Results:The level of SBP,TC,TG,MPV and PDW in MAU group were significantly higher than those in normal abuminuria group,and the level of HDL in MAU group were lower than that in normal abuminuria group(P < 0.05). The differences in WHR,SBP and TC between PAD and non-PAD group were statistically significant(P < 0.05). However,there was no significant difference in platelet parameters between two groups(P > 0.05). Logistic multiple regression analysis shown that SBP,TC,TG and PDW were the independent risk factors of the progress of MAU. SBP.WHR and HDL were significant factors for PAD(P > 0.05). Conclusion:Monitoring the platelet parameters,especially MPV and PDW,has very important prognostic value in the early diagnosis of microangiopathy in type 2 diabetes.关键词
2型糖尿病/血小板参数/微量白蛋白尿/外周血管病变Key words
type 2 diabetes/platelet parameters /microalbuminuria/peripheral arterial disease分类
医药卫生引用本文复制引用
杨俊,肖文金,胡吉,董吉祥,黄韵,张笑燕..血小板参数与2型糖尿病患者微量白蛋白尿及外周血管病变的关系[J].南京医科大学学报（自然科学版）,2012,32(10):1401-1404,4.
