南京医科大学学报（自然科学版）2012，Vol.32Issue(10)：1471-1475,5.
2005～2008年江苏省首次接受抗病毒治疗的艾滋病患者生存分析
Survival analysis of AIDS patients initially starting anti-retroviral therapy during 2005-2008 in Jiangsu province
摘要
Abstract
Objective:To analyze the survival rate of AIDS patients who initially received anti-retroviral therapy in 2005-2008 by the end of 2011, and to determine factors associated with survival status. Methods: Information of AIDS patients initially starting anti-retroviral therapy during 2005-2008 was collected from Chinese HIV/AIDS Integrated Control System. Kaplan-Meier was applied to make survival curve;and Cox proportional hazard regression model was used to determine associated factors of survival status. Results: Totally 451 cases were analyzed. The gender ratio of man to women was 1.75:1. Most of participants were married or cohabitated, with 20 to 50 years old. The major transmitted route was heterosexual. Most of participants were from southern area of Jiangsu. At baseline,average CD4+ T cell counts were 107/mm3. Accumulative survival rates in 12th,24th,36th,48th and 60th after therapy were 0.88,0.85,0.84,0.78 and 0.78 respectively. 53.6% of participants died within the first six months of therapy. CD4+ T cell counts at baseline,initial therapy schedule,and therapy schedule changed were found to be associated with survival time of patients. Conclusion: Anti-retroviral therapy improved the survival rate of AIDS patients. Starting therapy earlier can get better treatment result.关键词
艾滋病/抗病毒治疗/生存分析Key words
acquired immunodeficiency syndrome/anti-retroviral therapy/survival analysis分类
医药卫生引用本文复制引用
丁萍,傅更锋,张正红,陈国红,徐晓琴,邱涛,徐金水,李雷,胡海洋,羊海涛..2005～2008年江苏省首次接受抗病毒治疗的艾滋病患者生存分析[J].南京医科大学学报（自然科学版）,2012,32(10):1471-1475,5.基金项目
江苏省预防医学科研课题(Y2012069) （Y2012069）
江苏省卫生厅医学重点人才项目(RC2011087,RC2011086) （RC2011087,RC2011086）
