内科理论与实践2012，Vol.7Issue(6)：443-447,5.DOI:10.3969/j.issn.1673-6087.2012.06.012
代谢综合征增加动脉硬化患病风险
Metabolic syndrome associated with increased risk of arteriosclerosis
摘要
Abstract
Objective To investigate whether metabolic syndrome and increase in number of metabolic syndrome components will increase the risk of arteriosclerosis in middle-aged and elderly Chinese population. Methods Two thousand five hundred and nineteen subjects aged 40 years or older from Jiading district, Shanghai, were recruited to undergo questionnaire interview, anthropometric measurements, biochemical evaluation, and brachial-ankle pulse wave velocity (baPWV) measurement. Statistical analysis was performed on 2 097 subjects (876 male and 1 221 female) with complete data. baPWV > 1 753 cm/s was defined as having arteriosclerosis. Metabolic syndrome was diagnosed according to the criteria of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III )(NCEP-ATP III ). Multiple linear regression analysis and logistic regression analysis were performed to assess the correlation of metabolic syndrome and its components with arteriosclerosis. Results No statistically significant difference was seen between the prevalence of arteriosclerosis in male and female ( 23.64% and 25.61%, P = 0.195 2). The prevalence of metabolic syndrome in male was significantly lower than that in female ( 31.28% and 35.71%, P=0.034 5). With the increase in number of metabolic syndrome components from one to five, the prevalence of arteriosclerosis increased from 2.69%, 20.19%, 29.81%, 28.74% to 37.16% ( trend P < 0.000 1). In multiple stepwise linear regression analysis, systolic blood pressure (SBP), fasting plasma glucose (FPG) and triglycerides (TG) showed a close relationship with baPWV (?values were 0.46, 0.08 and 0.08, respectively; all P <0.000 1). Logistic regression analysis showed that, after adjusting the confounding factors, each increase in number of metabolic syn- drome components by one had 1.46-fold increase of risk of arteriosclerosis (95%CI: 1.29-1.67, P<0.000 1), and the risk of arteriosclerosis in subjects with metabolic syndrome was 1.53-fold of those without metabolic syndrome (95%CI: 1.13-2.08, P=0.006 0). Conclusions Metabolic syndrome and increase in number of metabolic syndrome components increased the risk of arteriosclerosis in middle-aged and elderly Chinese population.关键词
代谢综合征/动脉硬化/肱-踝动脉脉搏波传导速度Key words
Metabolic syndrome/Arteriosclerosis/Brachial-ankle pulse wave velocity分类
医药卫生引用本文复制引用
陆骆,宁光,张婕,李勉,任晨曦,孙婉婉,黄飞,徐佰慧,毕宇芳,陈宇红..代谢综合征增加动脉硬化患病风险[J].内科理论与实践,2012,7(6):443-447,5.基金项目
国家自然科学基金(项目编号:81170739) （项目编号:81170739）
上海自然科学基金(项目编号:10ZR1426400) （项目编号:10ZR1426400）
