四川医学2012，Vol.33Issue(8)：1487-1490,4.
帕金森病患者外周血T淋巴细胞亚群检测及临床意义
Changes of T lymphocyte subgroups in peripheral blood of Parkionson's disease patients
余能伟 1刘洁 1李晓佳 1张剑波 1杨友松 1孙红斌1
作者信息
- 1. 四川省医学科学院·四川省人民医院神经内科,中心实验室,四川成都610072
- 折叠
摘要
Abstract
Objective To provide experimental evidences partly for cell immunity and Parkinson's disease (PD) through T lymphocyte subgroups detected in peripheral blood. Methods We detected the changes of T lymphocyte subgroups by flow cy-tonletry Results The changes of T lymphocyte subgroups; CD3 + % (64. 77 ± 10. 76) and CD8 + % (28. 24 ± 9. 39) in PD patients are higher than those in healthy controlled group with significiant differences, P ＜ 0. 05; CD4 + % ( 33- 55 ± 6. 84) and CD4 +/CD8 + ( 1. 31 ±0. 55)are lower than those in controlled group with great significant differences, P ＜0. 01; There is no significant difference between drug taken and without drug taken patients in CD3 + %、 CD4 + % 、 CD8 + % 、 CD4 + /CD8 + ( P ＞ 0. 05). There were no correlation between the results of T lyMphocyte subgroups in blood and drug intaken, age, course, Webster scale, H-Y grade and UPDRS scale. Conclusion (1)PD patients suffer from imbalance between T lyMphocyte subgroups in peripheral blood; The attack of PD resulted from cell immune imbalance. (2)The changes of cell immune is not resulted from dopa-mine intaken, which suggest that PD patients' neuroimmune net is dysfunction.关键词
帕金森病/细胞免疫/T淋巴细胞亚群Key words
Parkinson's disease/ cell immunity/ T lymnhocvte suberouns分类
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余能伟,刘洁,李晓佳,张剑波,杨友松,孙红斌..帕金森病患者外周血T淋巴细胞亚群检测及临床意义[J].四川医学,2012,33(8):1487-1490,4.
