山东医药2012，Vol.52Issue(37)：11-13,3.
天麻钩藤饮、温胆汤、血府逐瘀汤对自发性高血压大鼠心肌组织与血浆ALDO和AngⅡ的影响
Effect of Tianma goutengyin, Wendan tang and Xuefuzhuyu tang on ALDO and Angll level in myocardial tissue and plasma of spontaneous hypertensive rats
摘要
Abstract
Objective To study effect of Tianma gouteng yin, wendan tang, Xuefuzhuyu tang, on the level of aldoste-rone (ALDO) and angiotensin II (AngII ) in myocardial tissue and plasma of spontaneously hypertensive rat (SHR). Methods Fifty 16-weeks-old spontaneous hypertensive rats (SHR) were randomly divided into 5 groups, namely SHR control group, captopril group, Tianmagouteng yin group, Wendantang group and Xuefuzhuyu tang group, each group includes 10 rats, meanwhile, to pick up 10 rats with normal blood pressure as normal control group. Those groups were given corresponding drugs by gastric perfusion, SHR control group and normal control group were given the same amount of saline , continuous treated for 8 weeks. Before and after treatment the levels of Ang II , ALDO in plasma and myocardium tissue were detected by radioimmunoassay. Results After 8 weeks' therapy, the results showed that captopril, Tianmagouteng yin, Wendan tang and Xuefuzhuyu tang can significantly decreased the levels of ALDO and Ang II in plasma and myocardium of SHR ( P < 0.01). Compared with SHR group and normal control group, there were significant differences (P < 0.01). Conclusion Tianmagouteng yin, Xuefuzhuyu tang and Wendan tang can significantly decrease the levels of Ang II , ALDO in myocardial tissue and plasma of SHR, and they also can resist myocardial fibrosis. its mechanism may be related to the inhibition of renin-angiotensin-aldosterone system.关键词
高血压/天麻钩藤饮/温胆汤/血府逐瘀汤/醛固酮/血管紧张素Ⅱ/自发性高血压大鼠Key words
hypertension/ Tianmagouteng yin/ Wendan tang/ Xuefuzhuyu tang/ aldosterone/ angiotensin II /spontaneously hypertensive rat分类
医药卫生引用本文复制引用
张国华,吕琳..天麻钩藤饮、温胆汤、血府逐瘀汤对自发性高血压大鼠心肌组织与血浆ALDO和AngⅡ的影响[J].山东医药,2012,52(37):11-13,3.基金项目
国家自然科学基金资助项目(81072937). （81072937）
