山东医药2012，Vol.52Issue(38)：1-4,4.
APC基因启动子区甲基化及环境因素与前列腺癌关系研究
Methylation status in promoter of APC and environmental factors with the predisposition to prostate cancer
摘要
Abstract
Objective To investigate the relationship between methylation status of adenomatosis polyposis coli gene ( APC) promoter and environmental factors in the predisposition of prostate cancer (Pea) in Chinese. Methods Bisulphite sequencing PCR were used to detect the expression of APC genes in prostate cancer tissues from 60 patients and hy-perplastic tissues from 40 benign prostate hyperplasia ( BPH) patients. Environmental risk factors related with Pca were also collected including demographic information, body mass index (BMI) , drinking, tea drinking, smoking, sports. Relationship between methylation of APC gene, environmental risk factors and the PCa prevalence was analysised by using uni-variate and multivariate method. Results The methylation rates of CG sites in promoter of APC genes were 14. 00% in PCa and 1. 19% in BPH. Methylation rate in APC genes was associated with PSA, Gleason score, pathologic stage. PCa was correlated with drinking habit of wire (OR = 2.46) or tea ( OR = 0. 29). Conclusions The methylation of promoter in APC genes is related to the development of PCa and the classification of risk. Methylation of APC genes may serve as a promising method for early diagnosis of PCa. The drinking habit of wine or tea is also a risk factor for PCa.关键词
前列腺癌/APC基因/甲基化/环境危险因素Key words
prostate cancer/ adenomatosis polyposis coli gene/ methylation/environmental factors分类
医药卫生引用本文复制引用
张连升,梁永,崔飞伦..APC基因启动子区甲基化及环境因素与前列腺癌关系研究[J].山东医药,2012,52(38):1-4,4.基金项目
江苏省自然科学基金资助项目(BK2011483). （BK2011483）
