山东医药2012，Vol.52Issue(39)：1-4,4.
超顺磁性氧化铁纳米粒子的制备、表征及生物相容性研究
Preparation, characterization and biocompatibility of Fe3O4 magnetic mnanoparticles
摘要
Abstract
Objective To evaluate the preparation, characterization and biocompatibility of Fe3O4 magnetic mnanop-articles for the treatment of tumor by magnetohydrodynamic heat therapy, so to lay the foundations for its application. Methods Fe3O4 magnetic nanoparticles were prepared through co-precipitation method. The appearance, phase constitue, function groups and magnetic susceptibility were characterized by transmission electron microscope ( TEM) , X-RAY powder diffraction (XRD) , scanning electron microscope-energy dispersive spectrum (SEM-EDS) and vibrating sample magnetometer ( VSM) ; MTT assay was used to investigate the in vitro toxicity and hemolysis test was carried out to estimate whether it had blood toxicity; Fe3 O4 suspension was intraperitoneally injected into KM mouse to calculate the acute toxicity; micronu-cleus ( MN) were reckoned to identify whether it was genotoxic. Results TEM showed the shapes of Fe3O4 nanoparticles to be approximately global and the size was estimated to be about 23 nm; XRD comparing with powder diffraction file of spinel Fe3 O4 nanomaterials by JCPDS indicated only spinel pHase; The components of 0 and Fe were determined; the toxicity to L-929 cell was between 0-1 degree and it had no hemolysis activity; No genotoxic effects were found. Conclusion The serf-prepared nanosized Fe3 O4 is a kind of high biocompatibility materials and is suitable for further application in tumor hy-perthermia.关键词
超顺磁性氧化铁纳米粒/生物相容性/磁流体热疗Key words
Fe3O4 magnetic nanoparticles/ biocompatibility/ magnetohydrodynamic heat therapy分类
医药卫生引用本文复制引用
陈道桢,项达军,李向东,唐秋莎,许飞,臧嘉,张婷,陆牡丹,杨岚,王家俊..超顺磁性氧化铁纳米粒子的制备、表征及生物相容性研究[J].山东医药,2012,52(39):1-4,4.基金项目
国家自然科学基金资助项目(30872999,30500601) （30872999,30500601）
江苏省六大人才高峰资助项目(2010-WS-062),江苏省"科教兴卫工程"专项经费资助项目(RC2011033),新疆自治区援疆干部人才创新创业计划. （2010-WS-062）
