山东医药2012，Vol.52Issue(39)：21-23,3.
PGC-1α基因G1y482Ser多态性与广西地区汉族人群妊娠期糖尿病的相关性分析
Gly482Ser variability analysis of peroxisome proliferator-activated receptor-γ coactivator-1 α(PGC-1 α) gene in Guangxi Han population with gestational diabetes mellitus
摘要
Abstract
Objective To investigate the relationship between the Gly482Ser single nucleotide polymorphism (SNP) of PGC-1α gene and gestational diabetes mellitus (GDM) of Guangxi Han population in China. Methods A case-control study involving 234 subjects, 84 of whom were GDM and 150 were non-diabetic pregnant women. Gly482Ser polymorphism of PGC-1α gene was analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and its correlation with GDM were analyzed. Results No significant difference was found in allele distribution and genotype frequency of PGC-1α SNP between the two groups. Conclusions The Gly482Ser SNP of PGC-1α gene is not associated with the occurrence of GDM of Guangxi Han population in China.关键词
过氧化物酶增殖物激活受体-γ辅助激活因子-1α基因,Gly482Ser,单核苷酸多态性/聚合酶链式反应/妊娠期糖尿病Key words
peroxisome proliferator-activated receptor-g coactivator-1α/ Gly482Ser/ single nucleotide polymorphism/ polymerase chain reaction/ gestational diabetes mellitus分类
医药卫生引用本文复制引用
庞静,颜晓东,莫晓云,王琳,路文盛..PGC-1α基因G1y482Ser多态性与广西地区汉族人群妊娠期糖尿病的相关性分析[J].山东医药,2012,52(39):21-23,3.基金项目
国家自然科学基金资助项目(30860113) （30860113）
广西卫生厅重点项目(桂重200736) （桂重200736）
广西卫生厅自筹项目(桂Z2007144). （桂Z2007144）
