山东医药2012，Vol.52Issue(39)：27-29,3.
人子宫颈癌组织PD-L1表达及其与HPV16E6/E7的相关性
PD-L1 expression and its association with HPV16E6/E7 in human cervical carcinoma
摘要
Abstract
Objective To investigate the role of programmed death 1 ligand 1 ( PD-L1) in the occurrence and development of cervical carcinoma. Methods The protein expression of PD-L1, Human papilloma virus 16 type E6 / E7 ( HPV16E6/E7) were examined in 40 samples of cervical carcinoma (cervical carcinoma group) ,25 samples of cervical in-traepithelial neoplasma ( CIN group ) and 8 samples of normal cervical tissue ( control group) by immunohistochemical SABC method and RT-PCR,the correlation between the two indexes was analyzed. Results PD-L1 and HPV16E6/E7 expressed in the cervical carcinoma group and CIN group,and the level in the former were significantly higer (P< 0. 01) ; there was a significant positive correlation between PD-L1 and HPV16E6/E7,r = 0.531, P<0.01. Conclusions PD-L1 can promote the development of cervical carcinoma.关键词
程序性死亡配体1/宫颈癌/人乳头瘤病毒16型E6/E7Key words
programmed death 1 ligand 1/ cervical carcinoma/ human papilloma virus 16 type E6 / E7分类
医药卫生引用本文复制引用
赵琳,李志英,刘朝奇,鲁选文..人子宫颈癌组织PD-L1表达及其与HPV16E6/E7的相关性[J].山东医药,2012,52(39):27-29,3.基金项目
湖北省教育厅自然科学研究重点项目(D20121308). （D20121308）
