山东医药2012，Vol.52Issue(41)：12-14,3.
T细胞淋巴瘤患者外周血内皮祖细胞的变化及其临床意义
Change of EPCs in peripheral T-cell lymphomas and its significance
摘要
Abstract
Objective To investigate the number change of EPCs in peripheral blood of PTCL patients and its significance. Methods The relative number(RN) and absolute number(AN) of EPCs were determined by FCM method in 25 patients with PTCL-NOS and 10 normal controls. The change of EPCs in peripheral blood before and after treatment was observed , and the relation between this change and clinical character of patients analyzed. Results The number of EPCs in the peripheral blood of patients with PTCL-NOS before treatment was significantly higher than that in control group (all P < 0.01). The number of EPCs of PTCL-NOS patients after treatment was differently decreased compared with that before treatment (all P <0.01). EPCs in effective group of PTCL-NOS initial treatment patients were lower than those in refractoriness group. Pearson correlation analysis showed that there was positive correlation between the number of EPCs and LDH, β2-MG and IPI(Correlation coefficients were 0.523, 0.476, 0.421,respectively;all P<0.05). The survive curve had dif-ferencet of AN of EPCs between groups < 20 μL and > 20 μL before 60 weeks while without difference after 60 weeks. Conclusions EPCs may be correlated with progression of the disease in a certain degree. Dynamic observation with the level of EPCs may be used to evaluate the treatment outcomes and act as a prognostic marker for PTCL-NOS.关键词
淋巴瘤,外周T细胞,非特异型/内皮祖细胞/流式细胞术Key words
lymphomas, peripheral T-cell, not specified/ endothelial progenitor cells/ flow lytometry technique分类
医药卫生引用本文复制引用
申政磊,朱萍,毛文文,梁进,沈丽达,王存德,尹列芬,杨玲..T细胞淋巴瘤患者外周血内皮祖细胞的变化及其临床意义[J].山东医药,2012,52(41):12-14,3.基金项目
云南省教育厅基金重点资助项目(09Z0031). （09Z0031）
