山东医药2012，Vol.52Issue(41)：26-28,3.
单肺通气模式下不同水平PEEP对肺损伤的影响
Effect of different PEEP on lung injury of esophageal cancer patients during one-lung ventilation
摘要
Abstract
Objective To investigate the influence of different PEEP level on lung injury. Methods Sixty patients with esophageal cancer were randomly divided into three groups of A, B and C, 20 cases in each group. A group: one lung ventilation with tidal volume 6 ml/kg +0 cmH2O PEEP; B group: one lung ventilation with tidal volume 6 mL/kg +4 cmH20 PEEP; C group: one lung ventilation with tidal volume 6 ml/kg + 8 cmH20 PEEP. In all the patients there were continual one lungventilation until the end of operation, Precluding patients with the bad lung function or lung disease, before one-lung ventilation (T1) , 30 min following OLV (T2) , 60 min following OLV (T3), 90 min following OLV (T4) , the end of the OLV (T5) , end of operation(T6), the MAP, HR, SpO2 were detected, meanwhile collecting 5 mL blood from verty to determin the TNF-α and IL-6 level. Results There was no significant difference of MAP, HR, SpO2 at different time point among the three goups. Inflammatory factors in B, C group were lower than those in A group( P <0.05 ) , but there was no difference between B and C group. Conclusion One-lung ventilation with tidal volume 6 mL/kg + 4 cmH2O PEEP do the lowest harm to lung.关键词
肺损伤/单肺通气/呼气末正压通气Key words
lung injury/ onelung ventilation/ positive end expiratory pressure分类
医药卫生引用本文复制引用
刘敏肖,郝立迎,王勇,任昉英..单肺通气模式下不同水平PEEP对肺损伤的影响[J].山东医药,2012,52(41):26-28,3.基金项目
河北省科技厅课题(10276171). （10276171）
