活性维生素D3对输尿管结扎小鼠肾组织胶原Ⅳ蛋白表达的影响OACSTPCD
1,25-dihydroxyvitamin D3ameliorates renal interstitial fibrosis in mice
目的 通过观察活性维生素D3[1,25-(OH) 2VitD3,活性VitD3]对单侧输尿管结扎(unilateral ureteral obstruction,UUO)的CD-1小鼠肾组织胶原Ⅳ蛋白(collagen Ⅳ)表达的研究,探讨活性VitD3阻止肾组织纤维化作用的机制.方法 42只CD-1小鼠随机分成假手术组(n=6)、UUO组(n=18)、UUO加活性VitD3治疗组(n=18),治疗组再分为0.5、0.25、1.0μg/kg 3个…查看全部>>
Objective To investigate the effect of 1,25-(OH)2VitD3 on renal fibrosis in unilateral ureteral obstruction (UUO) of mice. Methods Forty-two male CD-I mice were randomly assigned to three groups: Sham-operated group (n =6) , UUO group (n = 18) and UUO plus 1,25-(OH)2VitD3 (0.5, 0.25, 1. 0 (xg/kg) group (n = 18). Mice of UUO group were sacrificed 3, 7, 14 d after operation, other groups were sacrificed 7d after operation. The expression of collagen Ⅳ in rena…查看全部>>
李瑾;李微;殷少军;陈维杰
同济大学附属第十人民医院老年科,上海 200072同济大学附属第十人民医院老年科,上海 200072同济大学附属第十人民医院老年科,上海 200072同济大学附属第十人民医院老年科,上海 200072
医药卫生
活性维生素D3胶原Ⅳ肾间质纤维化
1,25-( OH) 2VitD3 collagen Ⅳ renal interstitial fibrosis
《同济大学学报（医学版）》 2012 (5)
41-44,4
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