同济大学学报（医学版）2012，Vol.33Issue(5)：62-65,4.DOI:10.3969/j.issn1008-0392.2012.05.014
成人急性B淋巴细胞白血病免疫表型分析
Analysis of immunophenotype of B lineage acute lymphoblastic leukemia in adult patients
摘要
Abstract
Objective To investigate the immunophenotype of B cell acute lymphoblastic leukemia in adult patients. Methods Immunophenotyping was performed by flow cytometry in 145 adult patients with B cell acute lymphoblastic leukemia. Results The highest incidence of lymphoid associated antigens were CD19, HLA-DR and CD79a,followed by CD34, CD10 and CD20. B-ALL had a higher expression rate of myeloid antigens CD13, CD33 and CD15, CD117 and T antigens (CD7 and CD56) were rarely expressed. Subtype II (CD10 + /CD34+ ) was predominant in three age groups of adults. The LAIP was observed in 100.0% and 90. 1% patients of subtype Ⅰ and subtype Ⅱ , respectively, whereas only 72. 7% and 63. 6% in subtype HI and subtype IV. There was no significant difference in incidence of LAIP between three age groups (P ＞ 0.05). Conclusion The immunophenotype by flow cytometry is of great value in correct diagnosis and minimal residual disease detection of B cell acute lymphoblastic leukemia.关键词
急性B淋巴细胞白血病/白血病相关免疫表型/流式细胞术Key words
B cell acute lymphoblastic leukemia/ leukemia associated immunophenotypes/ flow cytometry分类
医药卫生引用本文复制引用
孙慧,王倩,张之芬,武焕玲,田文君,刘斌..成人急性B淋巴细胞白血病免疫表型分析[J].同济大学学报（医学版）,2012,33(5):62-65,4.基金项目
山东省优秀中青年科学家科研奖励基金(BS2012YY025) （BS2012YY025）
