同济大学学报（医学版）2012，Vol.33Issue(5)：115-118,124,5.DOI:10.3969/j.issn1008-0392.2012.05.027
自噬及其在肿瘤中的作用
Autophagy and its role in oncogenesis
摘要
Abstract
Autophagy is a process by which stimulated cells phogocytize own intracellular cytoplasm or organelles and eventually are degraded in lysosomes. Both being patterns of programmed cell death, there are similarities as well as differences between autophagy and apoptosis. The regulatory mechanisms of autophagy are very complex and highly conserved, which may be associated with PI3K-Akt-mTOR, class III PI3K complex and RAS-RAF-1-MEK- ERK1/2 signaling translations. Currently it is revealed that there are several genetic links between autophagy defects and cancer. However, the molecular mechanisms by which autophagy functions in tumor suppression are poorly defined. Increasing evidence suggests that the tumor suppressor functions of autophagy may be related to both its potential prodeath and prosurvival effects.关键词
自噬/调节机制/肿瘤Key words
autophagy/ regulatory mechanism/ neoplasm分类
医药卫生引用本文复制引用
陈聪颖..自噬及其在肿瘤中的作用[J].同济大学学报（医学版）,2012,33(5):115-118,124,5.基金项目
国家自然科学基金(81072005) （81072005）
上海市科委项目(09410705400,10ZR1423300) （09410705400,10ZR1423300）
