生命科学研究2012，Vol.16Issue(5)：457-461,5.
神经富亮氨酸重复家族成员LRRN3的研究进展
Progresses in LRRN3, a Member of Neural Leucine-rich Repeat Protein Family
摘要
Abstract
As a member of neural leucine-rich repeat protein family, LRRN3 is an evolutionarily conserved transmembrane protein with diverse functions. LRRN3 is composed of a number of consecutive LRR domains, fibronectin type DI -like domain (FN11) and immunoglobulin-like C2 type domain (IgC2). It regulates the development of neural system through mediating cell adhesion. It has been well demonstrated that LR-RN3 not only participates in neural development, differentiation and damage repair, but also relates to the occurrence of mental disorders such as autism. Although LRRN3 plays an essential role in the development of neural system, little is know about its function, mechanism as well as clinical significance. The structure and function of LRRN3 as well as its relationship with human diseases are reviewed.关键词
LRRN3/神经系统/发育/损伤修复Key words
LRRN3/neural system/development/damage repair分类
生物科学引用本文复制引用
张喆,黄河..神经富亮氨酸重复家族成员LRRN3的研究进展[J].生命科学研究,2012,16(5):457-461,5.基金项目
国家自然科学基金资助项目(81141068) （81141068）
